Article

A general approach to reduce off-target radioactivity in vivo via Tetrazine-Knock-Out (TKO)

2024-06-02

Abstract excerpt

Monoclonal antibodies have had a remarkable impact on cancer therapy due to their high target specificity. However, their large molecular weight results in slow blood clearance, which can take weeks to clear from circulation. As companion nuclear imaging and diagnostic tools, these characteristics force delayed imaging and the use of isotopes with long half-lives such as 89 Zr. For optimal clinical application, i...

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Literature Corpus work: fe4db33c-4678-5a16-809b-b54844e288f9
DOI: 10.1101/2024.05.30.596510

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