Article

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18 labeled tetrazine

2025-08-07

Abstract excerpt

<title>Abstract</title> <p>Background Antibody-based positron emission tomography (PET) imaging holds great promise for visualizing disease-related proteins in the brain. However, its clinical utility is limited by poor antibody penetration across the blood-brain barrier (BBB) and the requirement for long-lived radionuclides due to slow antibody pharmacokinetics. Pretargeted imaging strategies, in which antibody...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d03d6e44-5462-5c06-8597-5a9357f634b1
DOI: 10.21203/rs.3.rs-7235104/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18 labeled tetrazineDOI 10.21203/rs.3.rs-7235104/v1Read

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18 labelled tetrazineSemantic proximity Read

Radionuclide selection influences imaging outcomes in immunoPET with a brain-penetrant anti-Aβ antibodySemantic proximity Read

A general approach to reduce off-target radioactivity in vivo via Tetrazine-Knock-Out (TKO)Semantic proximity Read

Investigation of the Impact of the H310A FcRn Region Mutation on 89Zr-Immuno-PET Brain Imaging with a BBB-Shuttle Anti‑Amyloid Beta Antibody.Semantic proximity Read

Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s diseaseSemantic proximity Read

Brain-Penetrating Peptide and Antibody Radioligands for Proof-of-Concept PET Imaging of Fibrin in Alzheimer’s DiseaseSemantic proximity Read

Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical.Semantic proximity Read

Engineering anti-amyloid antibodies with transferrin receptor targeting improves brain biodistribution and mitigates ARIASemantic proximity Read

Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8βSemantic proximity Read

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastomaSemantic proximity Read

A Metal-Free Method for Producing MRI Contrast at Amyloid-β.Semantic proximity Read

Pretargeted Imaging with Gallium-68 – Improving the Binding Capability by Increasing the Number of Tetrazine MotifsSemantic proximity Read