Article

IRF8 Governs Tumor-Associated Macrophage Control of T Cell Exhaustion

2020-03-14

Abstract excerpt

<h4>Summary</h4> Tumor progression is associated with overstimulation of cytotoxic T lymphocytes (CTLs), resulting in a dysfunctional state of exhaustion. How T cell exhaustion is elicited in the tumor remains poorly understood. Here we show that tumor-associated macrophages (TAMs) present cancer cell antigen and induce CTL exhaustion through a gene expression program dependent on the transcription factor interfe...

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Literature Corpus work: b30dc5fe-9d70-583e-bae2-31b8cd8c2369
DOI: 10.1101/2020.03.12.989731

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