Article

HDAC2 promotes autophagy-associated HCC malignant progression by transcriptionally activating LAPTM4B

2024-04-03

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC) is a significant global health challenge. The activation of autophagy plays an essential role in promoting the proliferation and survival of cancer cells. However, the upstream regulatory network of autophagy and its mechanism of regulation in HCC remains unclear. This study demonstrated that histone deacetylase 2 (HDAC2) is a target for regulating autopha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2a25d2e-6ff8-53bd-a8db-bef4643edd3f
DOI: 10.21203/rs.3.rs-4073777/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HDAC2 promotes autophagy-associated HCC malignant progression by transcriptionally activating LAPTM4BDOI 10.21203/rs.3.rs-4073777/v1Read

HDAC2 promotes autophagy-associated HCC malignant progression by transcriptionally activating LAPTM4BSemantic proximity Read

HDAC2 Provides a Critical Support to Malignant Progression of Hepatocellular Carcinoma through Feedback Control of mTORC1 and AKTSemantic proximity Read

ACAA2 was a predictor for the prognosis and immunotherapy response of hepatocellular carcinomaSemantic proximity Read

Histone demethylases in autophagy and inflammationSemantic proximity Read

ATF2 drives macrophage-mediated anti-PD-1 resistance by coupling KAT3A-dependent H3K18 lactylation with CCL2 transcription in hepatocellular carcinomaSemantic proximity Read

HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor EntitiesSemantic proximity Read

HDAC4 promotes the growth and metastasis of gastric cancer via autophagic degradation of MEKK3Semantic proximity Read

ALKBH5 promotes Liver hepatocellular carcinoma cell proliferation, migration and invasion by regulating TTI1 expressionSemantic proximity Read

Four Autophagy‐Related lncRNAs Predict the Prognosis of HCC through Coexpression and ceRNA MechanismSemantic proximity Read

Role of autophagy-related genes in liver cancer prognosisSemantic proximity Read

The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinomaSemantic proximity Read

HDAC6 Inhibition Extinguishes Autophagy in Cancer: Recent InsightsSemantic proximity Read