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Article

Bufalin stimulates antitumor immune response by driving tumor-infiltrating macrophage toward M1 phenotype in hepatocellular carcinoma.

Journal for immunotherapy of cancer - 1 May 2022

Yu Zhuo, Li Yuyao, Li Yue, Zhang Jinghao, Li Man, Ji Longshan, Tang Yifei, Zheng Yanxi, Sheng Jianguo, Han Qiucheng, Li Fu, Guo Jianfeng, Wang Lingtai, Sun Xuehua, Gao Yueqiu, Feng Hai

Abstract excerpt

BACKGROUND: Immunotherapy for hepatocellular carcinoma (HCC) exhibits limited clinical efficacy due to immunosuppressive tumor microenvironment (TME). Tumor-infiltrating macrophages (TIMs) account for the major component in the TME, and the dominance of M2 phenotype over M1 phenotype in the TIMs plays the pivotal role in sustaining the immunosuppressive character. We thus investigate the effect of bufalin on...

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Carcinoma, Hepatocellular
Cell Line, Tumor
Cytokines
Immunity
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Microenvironment

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Identifiers

PMID: 35618286
DOI: 10.1136/jitc-2021-004297
PMCID: PMC9125767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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