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Article

MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma.

Frontiers in immunology - 1 Jan 2026

An Xiuqin, Gao Yanfang, Zhao Shangyumeng, He Wei, Yang Xinda, Wu Yujie, Li Jihao, Yi Runxi, Han Yue, Li Mingxuan, Li Qiusheng, Yang Ting

Abstract excerpt

Background: Hepatocellular carcinoma (HCC) remains difficult to treat, and molecular determinants that link malignant behavior to the innate immune microenvironment are still needed. Methods: We integrated two-sample Mendelian randomization using cis-eQTL and cis-pQTL instruments with tumor transcriptomics, immune deconvolution, DNA methylation analyses, single-cell RNA sequencing, and loss-of-function assays to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 42220486
DOI: 10.3389/fimmu.2026.1849407
PMCID: PMC13215804

Genes

MAPRE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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