Article

Deletion of NLRP3 gene blocks traumatic brain injury induced abnormal immune response in 3xTg AD mice

2026-02-13

Abstract excerpt

Traumatic brain injury (TBI) is a significant risk factor for the development of Alzheimer’s disease (AD) and related dementia. In both TBI and AD, inflammation plays a pivotal role. It is known that NLRP3 inflammasome plays an important role in pathogenesis of AD while TBI triggers activation of NLRP3 inflammasome in the brain. To evaluate the importance of NLRP3 inflammasome in mediating TBI-induced immune respo...

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Literature Corpus work: 1cd21ed7-bb98-51e6-912c-f141d0e89f60
DOI: 10.64898/2026.02.11.705384

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