Article

Brain injury contributes to dopaminergic neurodegeneration, Lewy body pathology, and Parkinsonism preclinically with outcomes altered by T cell modulation

2025-09-17

Abstract excerpt

Traumatic brain injury (TBI) increases the risk of Parkinson’s disease (PD) development later in life, but much remains unknown regarding the mechanisms driving this relationship. A single, mild brain injury triggers resident and peripheral neuroinflammatory pathways that are similarly activated in PD patients, which could possibly increase susceptibility to neurodegeneration. In this study, we used preclinical mo...

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Literature Corpus work: 5aea442a-0c32-508f-be68-d13d917d4869
DOI: 10.1101/2025.09.16.676659

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