Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s disease

5 Jan 2019

Abstract excerpt

BACKGROUND: Immunologic abnormalities have been described in peripheral blood and central nervous system of patients suffering from Alzheimer's disease (AD), yet their role in the pathogenesis still remains poorly defined. AIM AND METHODS: We used the triple transgenic mouse model (3xTg-AD) to reproduce Aβ (amyloid plaques) and tau (neurofibrillary tangles) neuropathologies. We analyzed important features of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neurogenesis and neuroplasticity mechanisms
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30611289
DOI: 10.1186/s12974-018-1380-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s diseasePMID 30611289Read ↗

Age- and sex-dependent alterations in the peripheral immune system in the 3xTg-AD mouse model of Alzheimer's disease: Increased proportion of CD3+CD4-CD8- double-negative T cells in the bloodSemantic proximity Read ↗

Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory lossSemantic proximity Read ↗

Abnormal CD8 T cells induce and track Alzheimer’s-like neurodegenerationSemantic proximity Read ↗

Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice.Semantic proximity Read ↗

Interferon-γ Differentially Affects Alzheimer’s Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD MiceSemantic proximity Read ↗

Altered T-cell reactivity in the early stages of Alzheimer's diseaseSemantic proximity Read ↗

CCR6: a biomarker for Alzheimer's-like disease in a triple transgenic mouse model.Semantic proximity Read ↗

Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer’s disease-associated markers in 3xTg-AD miceSemantic proximity Read ↗

Adaptive immune changes associate with clinical progression of Alzheimer’s diseaseSemantic proximity Read ↗

β-Amyloids and Immune Responses Associated with Alzheimer’s DiseaseSemantic proximity Read ↗

IVIg protects the 3xTg-AD mouse model of Alzheimer's disease from memory deficit and Aβ pathology.Semantic proximity Read ↗

Altered T cell reactivity to β-amyloid-related antigens in early Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.