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Article

Association of the CX3CR1-V249I Variant with Neurofibrillary Pathology Progression in Late-Onset Alzheimer's Disease.

Molecular neurobiology - 1 Mar 2018

López-López Alan, Gelpi Ellen, Lopategui Diana Maria, Vidal-Taboada Jose M

Abstract excerpt

Neuroinflammation and microglial dysfunction have a prominent role in the pathogenesis of late-onset Alzheimer's disease (LOAD). CX3CR1 is a microglia-specific gene involved in microglia-neuron crosstalk and neuroinflammation. Numerous evidence show the involvement of CX3CR1 in AD. The aim of this study was to investigate if some functional genetic variants of this gene could influence on LOAD's outcome, in a...

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PMID: 28343297
DOI: 10.1007/s12035-017-0489-3

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