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Article

STING Signaling and Sterile Inflammation

1 Oct 2021

Abstract excerpt

Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely probe the local environment and maintain host integrity. Besides pathogen recognition through conserved motifs, several of these receptors also sense aberrant or misplaced self-molecules as a sign of perturbed homeostasis. Among them, self-nucleic acid sensing by the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon...

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PMID: 34659260
DOI: 10.3389/fimmu.2021.753789

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