Article

A non-canonical cGAS-STING pathway drives cellular and organismal aging

2025-04-04

Abstract excerpt

Accumulation of cytosolic DNA has emerged as a hallmark of aging, inducing sterile inflammation. STING (Stimulator of Interferon Genes) protein translates the sensing of cytosolic DNA by cGAS (cyclic-GMP-AMP synthase) into an inflammatory response. However, the molecular mechanisms whereby cytosolic DNA-induced cGAS-STING pathway leads to aging remain poorly understood. We show that STING does not follow the canon...

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Literature Corpus work: f7c0b478-a6f9-5ebb-a64a-1b7ad820f33c
DOI: 10.1101/2025.04.03.645994

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