Mutant p53 leads to low‐grade IFN‐I‐induced inflammation and impairs cGAS–STING signalling in mice

Abstract excerpt

Abstract Type I interferons (IFN‐Is) are a class of proinflammatory cytokines produced in response to viruses and environmental stimulations, resulting in chronic inflammation and even carcinogenesis. However, the connection between IFN‐I and p53 mutation is poorly understood. Here, we investigated IFN‐I status in the context of mutant p53 (p53 N236S , p53S). We observed significant cytosolic double‐stranded DNA...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cytokine Signaling Pathways and Interactions
• Share to Inflammasome and immune disorders
• Share to interferon and immune responses