Article

Innate Immune Priming by cGAS as a Preparatory Countermeasure Against RNA Virus Infection

2018-10-03

Abstract excerpt

The detection of nucleic acids by pattern recognition receptors is an ancient and conserved component of the innate immune system. Notably, RNA virus genomes are sensed by mammalian cytosolic RIG-I–like receptors, thereby activating interferon-stimulated gene (ISG) expression to restrict viral replication. However, recent evidence indicates that the cGAS-STING DNA sensing pathway also protects against RNA viruses....

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Literature Corpus work: 04ed3d0d-f5e8-5410-981c-db61f5456664
DOI: 10.1101/434027

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