Article

Programmable Nucleic Acid Sensing in Human Cells Using Circularizable ssDNA

2025-03-13

Abstract excerpt

Programmable technologies that sense specific nucleic acid signatures in living cells and trigger cellular functions hold significant potential for biotechnology and medicine. Here, we developed SONAR ( S ensing O f N ucleic acids using A SOs and R everse-transcriptases), a platform that enables the detection of target DNA and RNA sequences and triggers controlled gene expression in human cells. SONAR operate...

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Literature Corpus work: 1c739abc-7009-56d5-b60d-b48c74a52b4f
DOI: 10.1101/2025.03.12.642784

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