Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA-only cascade: a universal tool for signal amplification, enhancing the detection of target analytes.

Analytical chemistry - 16 Sept 2014

Bone Simon M, Hasick Nicole J, Lima Nicole E, Erskine Simon M, Mokany Elisa, Todd Alison V

Abstract excerpt

Diagnostic tests performed in the field or at the site of patient care would benefit from using a combination of inexpensive, stable chemical reagents and simple instrumentation. Here, we have developed a universal "DNA-only Cascade" (DoC) to quantitatively detect target analytes with increased speed. The DoC utilizes quasi-circular structures consisting of temporarily inactivated deoxyribozymes (DNAzymes). The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Catalytic
Share to Fluorescent Dyes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Meningococcal Infections

Share to Neisseria meningitidis

Share to Nucleic Acid Amplification Techniques

Share to Streptococcus

Source

Identifiers

PMID: 25157928
DOI: 10.1021/ac501811r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA-only cascade: a universal tool for signal amplification, enhancing the detection of target analytes.PMID 25157928Read ↗

Functional Nucleic Acids for Pathogenic Bacteria DetectionSemantic proximity Read ↗

One-pot Point-of-Care Nucleic-acid Detection via Padlock DNA Ligation and Rolling Circle TranscriptionSemantic proximity Read ↗

A Versatile DNAzyme‐Amplified Protease‐Sensing Platform for Accurate Diagnosis of SARS‐CoV‐2 and Reliable Classification of Colorectal CancerSemantic proximity Read ↗

Oligonucleotide aptamers for pathogen detection and infectious disease controlSemantic proximity Read ↗

Enhancement of CRISPR-Cas12a system through universal circular RNA designSemantic proximity Read ↗

Rolling-circle amplification in DNA diagnostics: the power of simplicity.Semantic proximity Read ↗

Visual “Dam-Break Drainage” Nucleic Acid Chips: Family-Affordable Platform for Rapid and Ultrasensitive Pathogens DetectionSemantic proximity Read ↗

Modular split-trigger cooperative activation enables a programmable Cas13-12 cascadeSemantic proximity Read ↗

Nuclease activity: an exploitable biomarker in bacterial infectionsSemantic proximity Read ↗

Programmable Nucleic Acid Sensing in Human Cells Using Circularizable ssDNASemantic proximity Read ↗

A rapid and ultrasensitive CRISPR-Cas12a assay for clinical detection of pathogens and mutations.Semantic proximity Read ↗

Programmable AND-gate strategy to reduce false positives in rolling circle amplification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.