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CRISPR-induced DNA reorganization for multiplexed nucleic acid detection

17 Mar 2023

Abstract excerpt

Nucleic acid sensing powered by the sequence recognition of CRIPSR technologies has enabled major advancement toward rapid, accurate and deployable diagnostics. While exciting, there are still many challenges facing their practical implementation, such as the widespread need for a PAM sequence in the targeted nucleic acid, labile RNA inputs, and limited multiplexing. Here we report FACT (Functionalized...

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PMID: 36932065
DOI: 10.1038/s41467-023-36874-6

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