Article

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

2020-06-10

Abstract excerpt

<h4>ABSTRACT</h4> SARS-CoV-2, the causative agent of COVID-19 1 , recognizes host cells by attaching its receptor-binding domain (RBD) to the host receptor ACE2 2–7 . Neutralizing antibodies that block RBD-ACE2 interaction have been a major focus for therapeutic development 8–18 . Llama-derived single-domain antibodies (nanobodies, ∼15 kDa) offer advantages including ease of production and possibility for dire...

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Literature Corpus work: 1afc6ea3-5241-5bd5-b357-516d4a8d94a9
DOI: 10.1101/2020.06.09.143438

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