Back to search

Article

A Nanobody as a Potent Angiogenesis Inhibitor That Targets the Orphan Receptor Tie1

2022-02-15

Abstract excerpt

<title>Abstract</title> <p>Human Tie1 and Tie2 receptor tyrosine kinases (RTKs) are signaling molecules with important pathophysiological functions in many diseases, including different cancers. Tie1, in particular, has been implicated in the promotion of tumor growth and cancer cell migration <italic>in vitro </italic>and <italic>in vivo</italic>. Tie1 activity is mediated mainly through the downstream angiopoie...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1367a8ad-3555-560e-a92c-80355b595439
DOI
10.21203/rs.3.rs-1330228/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Nanobody as a Potent Angiogenesis Inhibitor That Targets the Orphan Receptor Tie1DOI 10.21203/rs.3.rs-1330228/v1
Bispecific nanobody® as new pharmacological drug for the selective inhibition of Trypsin-3Semantic proximity
Specific targeting of MR1-antigen complexes using nanobodiesSemantic proximity
NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodiesSemantic proximity
Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library.Semantic proximity
NewroBus for the brain: humanized TfR1-targeting nanobodies with high BBB permeability and cargo transport capacitySemantic proximity
Evolution of nanobodies specific for BCL11ASemantic proximity
Allosteric inhibition of Aurora-A kinase by a synthetic V <sub>NAR</sub> nanobodySemantic proximity
GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeuticsSemantic proximity
Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation ToolboxSemantic proximity
Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseasesSemantic proximity
In vitro nanobody discovery for integral membrane protein targetsSemantic proximity
A general approach for selection of epitope-directed binders to proteinsSemantic proximity
Select a neighboring publication to make it the new centre.