Examining Alzheimer's Disease modifiable risk factors: Impact of physical activity and diet on neuroanatomy and behaviour in mouse models

Abstract excerpt

Dementia is a global public health challenge, with obesity emerging as an important modifiable risk factor. Here, we examined whether lifestyle interventions can mitigate the effects of diet-induced obesity on body weight, behaviour, and brain anatomy in mouse models. Using a longitudinal design, wild-type and triple-transgenic (3xTgAD) mouse models of Alzheimer's disease were exposed to a high-fat diet and assign...

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• Amyloid beta-Protein Precursor
• Learning
• Maze Learning
• Memory
• Mice, 129 Strain
• Neurofibrillary Tangles
• Plaque, Amyloid
• Regulation of Appetite and Obesity

Identifiers and source

Literature Corpus work

1c136b61-1350-5178-bec3-2f1b798d008f

DOI

10.1101/2025.02.26.640411