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Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning

27 Apr 2021

Abstract excerpt

A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and therapy-induced immune responses to these vectors. Recent advances in high-throughput DNA synthesis, multiplexing and sequencing technologies have accelerated engineering of improved capsid properties such as production yield, packaging efficiency, biodistribution and...

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PMID: 33986759
DOI: 10.3389/fimmu.2021.674021

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