Article

Larixol is not an inhibitor of Gα <sub>i</sub> containing G proteins and lacks effect on signaling mediated by human neutrophil expressed formyl peptide receptors

2023-10-11

Abstract excerpt

Neutrophils express several G protein-coupled receptors (GPCRs) connected to intracellular Gα i or Gα q containing G proteins for down-stream signaling. To dampen GPCR mediated inflammatory processes, several inhibitors targeting the receptors and/or their down-stream signals, have been developed. Potent and selective inhibitors for Gα q containing G proteins are available, but potent and specific inhibitors of...

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Literature Corpus work: 1bc96f2a-68a2-5e5f-bbb8-f45d9779feaa
DOI: 10.1101/2023.10.11.561907

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