Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis.

The Journal of biological chemistry - 9 Nov 2001

Seifert R, Wenzel-Seifert K

Abstract excerpt

The formyl peptide receptor (FPR) is a prototypical chemoattractant receptor expressed in neutrophils. It is well known that the FPR couples to G(i) proteins to activate phospholipase C, chemotaxis, and cytotoxic cell functions, but the in vivo role of the FPR in man has remained elusive. Recently, F110S and C126W mutations of the FPR have been associated with localized juvenile periodontitis. We studied...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aggressive Periodontitis
Share to Cells, Cultured
Share to Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gi-Go

Share to Guanosine 5'-O-(3-Thiotriphosphate)

Share to Receptors, Immunologic

Share to Receptors, Peptide

Share to Spodoptera

Source

Identifiers

PMID: 11559706
DOI: 10.1074/jbc.M106621200

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis.PMID 11559706Read ↗

Formyl Peptide Receptor Polymorphisms: 27 Most Possible Ways for Phagocyte Dysfunction.Semantic proximity Read ↗

Critical role of N-terminal N-glycosylation for proper folding of the human formyl peptide receptor.Semantic proximity Read ↗

Analysis of a missense variant of the human N-formyl peptide receptor that is associated with agonist-independent beta-arrestin association and indices of inflammation.Semantic proximity Read ↗

Visualizing the Dominant GPCR Coupling of Pathogenic Gαo Mutants in <i>GNAO1</i> -Related DisordersSemantic proximity Read ↗

In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activitySemantic proximity Read ↗

<i>In vitro</i> profiling of orphan G protein coupled receptor (GPCR) constitutive activitySemantic proximity Read ↗

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies.Semantic proximity Read ↗

Formylpeptide receptor single nucleotide polymorphism 348T>C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis.Semantic proximity Read ↗

Molecular biology for formyl peptide receptors in human diseasesSemantic proximity Read ↗

A constitutively active GPCR retains its G protein specificity and the ability to form dimers.Semantic proximity Read ↗

Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains.Semantic proximity Read ↗

Contrasting evolution of the human leukocyte N-formylpeptide receptor subtypes FPR and FPRL1R.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.