Article
The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35.
Molecular pharmacology - 1 Jan 2014
MacKenzie Amanda E, Caltabiano Gianluigi, Kent Toby C, Jenkins Laura, McCallum Jennifer E, Hudson Brian D, Nicklin Stuart A, Fawcett Lindsay, Markwick Rachel, Charlton Steven J, Milligan Graeme
Abstract excerpt
Lack of high potency agonists has restricted analysis of the G protein-coupled receptor GPR35. Moreover, marked variation in potency and/or affinity of current ligands between human and rodent orthologs of GPR35 has limited their productive use in rodent models of physiology. Based on the reported modest potency of the antiasthma and antiallergic ligands cromolyn disodium and nedocromil sodium, we identified the...
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