Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2016

Moraes Leonardo A, Unsworth Amanda J, Vaiyapuri Sakthivel, Ali Marfoua S, Sasikumar Parvathy, Sage Tanya, Flora Gagan D, Bye Alex P, Kriek Neline, Dorchies Emilie, Molendi-Coste Olivier, Dombrowicz David, Staels Bart, Bishop-Bailey David, Gibbins Jonathan M

Abstract excerpt

OBJECTIVE: Although initially seemingly paradoxical because of the lack of nucleus, platelets possess many transcription factors that regulate their function through DNA-independent mechanisms. These include the farnesoid X receptor (FXR), a member of the superfamily of ligand-activated transcription factors, that has been identified as a bile acid receptor. In this study, we show that FXR is present in human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic GMP
Share to Fibrinogen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemostasis

Share to Isoxazoles

Share to Platelet Activation

Share to Platelet Aggregation

Share to Platelet Aggregation Inhibitors

Share to Platelet Glycoprotein GPIIb-IIIa Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 27758768
DOI: 10.1161/ATVBAHA.116.308093
PMCID: PMC5144997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.PMID 27758768Read ↗

Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasisSemantic proximity Read ↗

Non-genomic effects of nuclear receptors: insights from the anucleate plateletSemantic proximity Read ↗

Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.Semantic proximity Read ↗

Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation.Semantic proximity Read ↗

Maresin 1 induces a novel pro-resolving phenotype in human platelets.Semantic proximity Read ↗

Overview of the P2 receptors.Semantic proximity Read ↗

Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolismSemantic proximity Read ↗

Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal MyofibroblastsSemantic proximity Read ↗

A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression.Semantic proximity Read ↗

Nuclear receptor FXR, bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations.Semantic proximity Read ↗

A new role for the A2b adenosine receptor in regulating platelet function.Semantic proximity Read ↗

Platelets from mice lacking the aryl hydrocarbon receptor exhibit defective collagen-dependent signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.