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THE ACTIN CYTOSKELETON CONTROLS NADPH OXIDASE ACTIVATION AND G PROTEIN RECRUITMENT MEDIATED BY NEUTROPHIL Gαq-COUPLED RECEPTORS

2025-06-02

Abstract excerpt

<h4>ABSTRACT</h4> Signaling by formyl peptide receptor 1 (FPR1), the prototype G protein-coupled receptor (GPCR) expressed in neutrophil leukocytes, is initiated by an activation of a G protein containing a Gα i subunit. FPR1 activation results in an increase in the cytosolic concentration of free calcium ions ([Ca 2+ ] i ), and an activation of the superoxide anion producing NADPH oxidase. Receptor downstream...

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Literature Corpus work: 1ed3474e-0be4-5fd0-b2eb-aeb3d1433370
DOI: 10.1101/2025.05.30.656946

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