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Article

Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Jun 2014

Fowler Stephanie W, Chiang Angie C A, Savjani Ricky R, Larson Megan E, Sherman Mathew A, Schuler Dorothy R, Cirrito John R, Lesné Sylvain E, Jankowsky Joanna L

Abstract excerpt

An unresolved debate in Alzheimer's disease (AD) is whether amyloid plaques are pathogenic, causing overt physical disruption of neural circuits, or protective, sequestering soluble forms of amyloid-β (Aβ) that initiate synaptic damage and cognitive decline. Few animal models of AD have been capable of isolating the relative contribution made by soluble and insoluble forms of Aβ to the behavioral symptoms and...

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Identifiers

PMID: 24899710
DOI: 10.1523/JNEUROSCI.0572-14.2014
PMCID: PMC4044248

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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