Article
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
Nature communications - 23 Apr 2021
Baglietto-Vargas David, Forner Stefania, Cai Lena, Martini Alessandra C, Trujillo-Estrada Laura, Swarup Vivek, Nguyen Marie Minh Thu, Do Huynh Kelly, Javonillo Dominic I, Tran Kristine Minh, Phan Jimmy, Jiang Shan, Kramár Enikö A, Nuñez-Diaz Cristina, Balderrama-Gutierrez Gabriela, Garcia Franklin, Childs Jessica, Rodriguez-Ortiz Carlos J, Garcia-Leon Juan Antonio, Kitazawa Masashi, Shahnawaz Mohammad, Matheos Dina P, Ma Xinyi, Da Cunha Celia, Walls Ken C, Ager Rahasson R, Soto Claudio, Gutierrez Antonia, Moreno-Gonzalez Ines, Mortazavi Ali, Tenner Andrea J, MacGregor Grant R, Wood Marcelo, Green Kim N, LaFerla Frank M
Abstract excerpt
The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. Remarkably, changing 3 amino acids in the mouse Aβ sequence to its...
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