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Article

Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation.

Acta neuropathologica communications - 22 Apr 2023

Célestine Marina, Jacquier-Sarlin Muriel, Borel Eve, Petit Fanny, Perot Jean-Baptiste, Hérard Anne-Sophie, Bousset Luc, Buisson Alain, Dhenain Marc

Abstract excerpt

Alzheimer's disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or tau proteins. These peptides and proteins induce synaptic dysfunctions that are strongly correlated with cognitive decline. Intracerebral infusion of well-defined Aβ seeds from non-mutated Aβ1-40 or Aβ1-42 peptides can increase Aβ depositions several months after the...

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Identifiers

PMID: 37087498
DOI: 10.1186/s40478-023-01559-0
PMCID: PMC10122826

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