Article

Luminal progenitors undergo partial epithelial-to-mesenchymal transition at the onset of basal-like breast tumorigenesis

2022-06-09

Abstract excerpt

<h4>SUMMARY</h4> Defects in double-strand repair mechanisms - both through germline or somatic inactivation of repair genes - is a hallmark of basal-like breast cancers. In this genetically-unstable context, a recurrent shift in cell identity occurs within the mammary epithelium. Basal-like tumors have indeed been proposed to originate from luminal progenitor (LP) cells yet tumor-initiating events remain poorly u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1bbc988e-54d0-5ab4-9f9a-64a981f49b0f
DOI: 10.1101/2022.06.08.494710

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Luminal progenitors undergo partial epithelial-to-mesenchymal transition at the onset of basal-like breast tumorigenesisDOI 10.1101/2022.06.08.494710Read

Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.Semantic proximity Read

A genetic mosaic mouse model illuminates the pre-malignant progression of basal-like breast cancerSemantic proximity Read

Germline <i>BRCA1</i> Mutation Deregulates Irradiation–Induced Cell Cycle Checkpoints in Human Mammary Luminal ProgenitorsSemantic proximity Read

Lineage plasticity enables low-ER luminal tumors to evolve and gain basal-like traitsSemantic proximity Read

Cell-type-specific epigenomic variations associated with <i>BRCA1</i> mutation in pre-cancer human breast tissuesSemantic proximity Read

Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast CancerSemantic proximity Read

Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesisSemantic proximity Read

Epigenetic changes with age primes mammary luminal epithelia for cancer initiationSemantic proximity Read

H3K27me3 is a determinant of chemotolerance in triple-negative breast cancerSemantic proximity Read

A luminal intermediate cell state maintains long-term prostate homeostasis and contributes to tumorigenesisSemantic proximity Read

Longitudinal single cell RNA-sequencing of <i>Pik3ca</i> <sup>H1047R</sup> -driven mammary tumorigenesis reveals coordinated transformation of epithelial and fibroblast transcriptional statesSemantic proximity Read

Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks.Semantic proximity Read