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Germline <i>BRCA1</i> Mutation Deregulates Irradiation–Induced Cell Cycle Checkpoints in Human Mammary Luminal Progenitors

2026-08-12

Abstract excerpt

Mammary ductal tree comprises two epithelial lineages, basal and luminal, which harbour stem and progenitor cell subsets essential to breast physiology and are cancer-initiating precursors. Dysregulated cellular stress response is an early event in tumorigenesis, yet lineage-rooted study of primary breast epithelium pertinent to familial mutation carriers is limited. Here, we establish a lineage-resolved monolayer...

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Literature Corpus work
bdc3db9b-0b49-51fa-a4d4-25cc2e9e8463
DOI
10.64898/2026.08.11.743512
Open publication

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Germline <i>BRCA1</i> Mutation Deregulates Irradiation–Induced Cell Cycle Checkpoints in Human Mammary Luminal ProgenitorsDOI 10.64898/2026.08.11.743512
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