Article

TAp73 mediates anti-tumor immunity through regulation of lipid metabolism in the lung tumor microenvironment

2025-11-24

Abstract excerpt

<h4>ABSTRACT</h4> While immunotherapy has become the standard of care for lung adenocarcinoma (LUAD) patients without actionable genomic alterations, only a subset of patients benefits from a long-lasting response to immunotherapy. Activation of p53-related signals has emerged as a potential mediator of the lung tumor microenvironment (TME). Given that mutant-p53 interacts with p73 extensively and TAp73-deficient...

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Literature Corpus work: 1ba71055-a2b9-5080-8eb8-b82a8e1be531
DOI: 10.1101/2025.11.21.689807

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