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Article

Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor Suppression

27 Jun 2018

Abstract excerpt

p53 has functional roles in tumor suppression as a guardian of the genome, surveillant of oncogenic cell transformation, and as recently demonstrated, a regulator of intracellular metabolism. Accumulating evidence has shown that the tumor microenvironment, accompanied by inflammation and tissue remodeling, is important for cancer proliferation, metastasis, and maintenance of cancer stem cells (CSCs) that...

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PMID: 29954119
DOI: 10.3390/cancers10070219

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