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Dual Role of p73 in Cancer Microenvironment and DNA Damage Response

13 Dec 2021

Abstract excerpt

Understanding the mechanisms that regulate cancer progression is pivotal for the development of new therapies. Although p53 is mutated in half of human cancers, its family member p73 is not. At the same time, isoforms of p73 are often overexpressed in cancers and p73 can overtake many p53 functions to kill abnormal cells. According to the latest studies, while p73 represses epithelial-mesenchymal transition and...

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PMID: 34944027
DOI: 10.3390/cells10123516

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