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Article

The impact of p53 mutation on tumor immune evasion: mechanistic insights and clinical implications.

Frontiers in immunology - 1 Jan 2026

Liang Luo, Wang Weidong

Abstract excerpt

Mutant p53(Mtp53) not only loses its canonical tumor-suppressive functions but also acquires oncogenic gain-of-function properties, positioning it as a central orchestrator in reshaping the tumor immune microenvironment. This review systematically delineates how Mtp53 actively establishes and sustains an immunosuppressive niche through multiple interconnected mechanisms, including chronic inflammation, immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41727427
DOI: 10.3389/fimmu.2026.1753215
PMCID: PMC12920560

Genes

TP53
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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