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p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells

21 Dec 2023

Abstract excerpt

gene is mutated in approximately 30% of all breast cancer cases. Adipocytes and preadipocytes, which constitute a substantial fraction of the stroma of normal mammary tissue and breast tumors, undergo transcriptional, metabolic, and phenotypic reprogramming during breast cancer development and play an important role in tumor progression. We report here that p53 loss in breast cancer cells facilitates the...

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PMID: 38127986
DOI: 10.1073/pnas.2311460120

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