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Article

Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism

27 Oct 2017

Abstract excerpt

The p53 family of transcription factors (p53, p63 and p73) covers a wide range of functions critical for development, homeostasis and health of mammals across their lifespan. Beside the well-established tumor suppressor role, recent evidence has highlighted novel non-oncogenic functions exerted by p73. In particular, p73 is required for multiciliated cell (MCC) differentiation; MCCs have critical roles in brain...

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PMID: 29077094
DOI: 10.1038/cdd.2017.178

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