Spatially confined sub-tumor microenvironments in pancreatic cancer.

doi:10.1016/j.cell.2021.09.022

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Article

Spatially confined sub-tumor microenvironments in pancreatic cancer.

Cell - 28 Oct 2021

Grünwald Barbara T, Devisme Antoine, Andrieux Geoffroy, Vyas Foram, Aliar Kazeera, McCloskey Curtis W, Macklin Andrew, Jang Gun Ho, Denroche Robert, Romero Joan Miguel, Bavi Prashant, Bronsert Peter, Notta Faiyaz, O'Kane Grainne, Wilson Julie, Knox Jennifer, Tamblyn Laura, Udaskin Molly, Radulovich Nikolina, Fischer Sandra E, Boerries Melanie, Gallinger Steven, Kislinger Thomas, Khokha Rama

Abstract excerpt

Intratumoral heterogeneity is a critical frontier in understanding how the tumor microenvironment (TME) propels malignant progression. Here, we deconvolute the human pancreatic TME through large-scale integration of histology-guided regional multiOMICs with clinical data and patient-derived preclinical models. We discover "subTMEs," histologically definable tissue states anchored in fibroblast plasticity, with...

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Identifiers

PMID: 34644529
DOI: 10.1016/j.cell.2021.09.022

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