Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years

Abstract excerpt

Abstract Background In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such asAPOE e4 (APOE4)genotype as well as associations to dementia-related biomarkers should be explored. Therefore, we examined the association ofAPOE4and various PRSs, based on training sets that utilized differing AD...

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