Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA.

Nature structural & molecular biology - 1 Mar 2014

Lou Xiaohua, Toresson Gudrun, Benod Cindy, Suh Ji Ho, Philips Kevin J, Webb Paul, Gustafsson Jan-Ake

Abstract excerpt

Nuclear receptors (NRs) are conditional transcription factors with common multidomain organization that bind diverse DNA elements. How DNA sequences influence NR conformation is poorly understood. Here we report the crystal structure of the human retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on its cognate element, an AGGTCA direct repeat spaced by 4 nt. The complex has an extended X-shaped...

Topics

DNA
DNA, Complementary
Escherichia coli
Humans
Ligands
Liver X Receptors
Models, Molecular
Mutation
Orphan Nuclear Receptors
Promoter Regions, Genetic
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Multimerization

Protein Structure, Tertiary

Retinoid X Receptor alpha

Zinc Fingers

Source

Identifiers

PMID: 24561505
DOI: 10.1038/nsmb.2778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA.PMID 24561505Read ↗

A Structural Signature Motif Enlightens the Origin and Diversification of Nuclear ReceptorsSemantic proximity Read ↗

Conformational Changes of RORγ During Response Element Recognition and Coregulator EngagementSemantic proximity Read ↗

Mutation of two residues converts the ligand-binding domain of RXRα into a uniform monomer without impairing the binding of retinoic acid and cofactors.Semantic proximity Read ↗

Interactions that determine the assembly of a retinoid X receptor/corepressor complex.Semantic proximity Read ↗

A canonical structure for the ligand-binding domain of nuclear receptors.Semantic proximity Read ↗

Structural Insights Into Thyroid Hormone ReceptorsSemantic proximity Read ↗

Multidomain integration in the structure of the HNF-4α nuclear receptor complex.Semantic proximity Read ↗

A comprehensive structural and functional analysis of the ligand binding domain of the nuclear receptor superfamily reveals highly conserved signaling motifs and two distinct canonical forms through evolutionSemantic proximity Read ↗

The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor.Semantic proximity Read ↗

Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements.Semantic proximity Read ↗

Signature of the oligomeric behaviour of nuclear receptors at the sequence and structural level.Semantic proximity Read ↗

Structure and Function of the Human Nuclear Xenobiotic Receptor PXRSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.