Article

Interplay of protein disorder in retinoic acid receptor heterodimer and its corepressor regulates gene expression

2018-10-25

Abstract excerpt

The retinoic acid receptors (RARs) form heterodimers with retinoid X receptors (RXRs) and control gene transcription in response to ligand binding and via allosteric activation of the C-termini helix (helix H12) of its ligand-binding domain. Herein we show that in the absence of ligand, helices H12 of RXR and RAR are disordered. The selective RAR agonist, Am580, induces folding of H12, whereas in the presence of...

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Literature Corpus work: 8300cfa4-87da-542d-b1cb-9ab55aca7728
DOI: 10.1101/452482

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