Article
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Nucleic acids research - 21 Aug 2017
Weikum Emily R, de Vera Ian Mitchelle S, Nwachukwu Jerome C, Hudson William H, Nettles Kendall W, Kojetin Douglas J, Ortlund Eric A
Abstract excerpt
The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that controls the expression of extensive gene networks, driving both up- and down-regulation. GR utilizes multiple DNA-binding-dependent and -independent mechanisms to achieve context-specific transcriptional outcomes. The DNA-binding-independent mechanism involves tethering of GR to the pro-inflammatory transcription factor activator...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.