Article

Adeno-to-squamous transition drives resistance to KRAS inhibition in <i>LKB1</i> mutant lung cancer

2023-09-10

Abstract excerpt

<h4>Summary</h4> KRAS G12C inhibitors including adagrasib and sortorasib have shown clinical promise in targeting KRAS G12C -mutated lung cancers, however, most patients eventually develop drug resistance. In lung adenocarcinoma patients with co-occurring KRAS G12C and STK11 / LKB1 mutations, we found a high squamous gene signature at baseline significantly correlated with poor adagrasib response. Through...

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Literature Corpus work: d5554010-eef3-5b2f-b111-9af7f0e73364
DOI: 10.1101/2023.09.07.556567

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