Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer.

doi:10.1016/j.ccell.2024.01.012

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Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer.

Cancer cell - 11 Mar 2024

Tong Xinyuan, Patel Ayushi S, Kim Eejung, Li Hongjun, Chen Yueqing, Li Shuai, Liu Shengwu, Dilly Julien, Kapner Kevin S, Zhang Ningxia, Xue Yun, Hover Laura, Mukhopadhyay Suman, Sherman Fiona, Myndzar Khrystyna, Sahu Priyanka, Gao Yijun, Li Fei, Li Fuming, Fang Zhaoyuan, Jin Yujuan, Gao Juntao, Shi Minglei, Sinha Satrajit, Chen Luonan, Chen Yang, Kheoh Thian, Yang Wenjing, Yanai Itai, Moreira Andre L, Velcheti Vamsidhar, Neel Benjamin G, Hu Liang, Christensen James G, Olson Peter, Gao Dong, Zhang Michael Q, Aguirre Andrew J, Wong Kwok-Kin, Ji Hongbin

Abstract excerpt

KRASG12C inhibitors (adagrasib and sotorasib) have shown clinical promise in targeting KRASG12C-mutated lung cancers; however, most patients eventually develop resistance. In lung patients with adenocarcinoma with KRASG12C and STK11/LKB1 co-mutations, we find an enrichment of the squamous cell carcinoma gene signature in pre-treatment biopsies correlates with a poor response to adagrasib. Studies of...

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Identifiers

PMID: 38402609
DOI: 10.1016/j.ccell.2024.01.012

Genes

KRAS
KRT6A
STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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