Article

Edited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis

2025-03-25

Abstract excerpt

Patho-mechanistic origins and disease dynamics of ulcerative colitis are still poorly understood. The actin-crosslinker Filamin A (FLNA) impacts cellular responses through interaction with cytosolic proteins. FLNA exists in two forms that differ only in one amino acid: genome-encoded FLNA Q and FLNA R - generated by post-transcriptional A-to-I editing. FLNA is edited in fibroblasts, smooth muscle- and endothelia...

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Literature Corpus work: 1b2c45a1-afc0-5297-a8c1-7b5fee662a17
DOI: 10.1101/2025.03.25.643676

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