Article
The filamins: organizers of cell structure and function.
Cell adhesion & migration - 1 Jan 2000
Nakamura Fumihiko, Stossel Thomas P, Hartwig John H
Abstract excerpt
Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in 1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered its isoforms (FLNb and c), and identified over 90 binding partners including channels, receptors, intracellular signaling molecules, and even transcription factors. Due to this diversity, mutations in human FLN genes result...
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