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Branched actin networks mediate macrophage-dependent host microbiota homeostasis

2024-07-18

Abstract excerpt

Assembly of branched actin networks, driven by the Arp2/3 complex are essential for the function and integrity of the immune system. Patients with loss-of-function mutations in the ARPC5 subunit of the Arp2/3 complex develop inflammation and immunodeficiency after birth, leading to early mortality. However, the mechanistic basis for these phenotypes remains obscure. Here we demonstrate that loss of Arpc5 in the mu...

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Identifiers and source

Literature Corpus work
1e15f971-0f2b-5e14-ab31-f5cfafbb744a
DOI
10.1101/2024.07.18.604111
Open publication

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Branched actin networks mediate macrophage-dependent host microbiota homeostasisDOI 10.1101/2024.07.18.604111
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