Article

Fine-Tuning Levels of Filamins A and B as a Specific Mechanism Sustaining Th2 Lymphocyte Functions

2024-03-15

Abstract excerpt

<title>Abstract</title> <p>Augmenting the portfolio of therapeutics for type 2-driven diseases is crucial to address unmet clinical needs and to design personalized treatment schemes. An attractive therapy for such diseases would consist in targeting the recruitment of T helper 2 (Th2) lymphocytes to inflammatory sites. Herein, we unravel the degradation of filamins (FLN) A and B by the ASB2α E3 ubiquitin ligase...

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Literature Corpus work: 7d604ad2-dc29-5101-ae72-f903e8844ef2
DOI: 10.21203/rs.3.rs-3878460/v1

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