Article

In vivo colonic epithelial cell editing attenuates intestinal inflammation in mice

2025-10-10

Abstract excerpt

Engineered epithelial cells with enhanced efferocytosis capacity promote inflammation resolution and restore tissue homeostasis. Here, we developed a therapeutic approach to generate efferocytosis boosting epithelial cells in vivo by delivering mRNA in lipid nanoparticles (LNPs). We demonstrate that LNP-mediated delivery of mRNA enables efficient in vitro and in vivo functional editing of epithelial cells. In muri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4e70cea-c723-549a-8d82-484f4bce2778
DOI: 10.1101/2025.10.08.678706

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In vivo colonic epithelial cell editing attenuates intestinal inflammation in miceDOI 10.1101/2025.10.08.678706Read

Nanoparticle-mediated gene therapy strategies for mitigating inflammatory bowel diseaseSemantic proximity Read

Efficient transgenesis and homology-directed gene targeting in monolayers of primary human small intestinal and colonic epithelial stem cellsSemantic proximity Read

Oral Spatiotemporal Nanoassembly for Sequential Genetic Reprogramming from Gut to Periphery OrganSemantic proximity Read

The use of plant-derived exosome-like nanoparticles as a delivery system of CRISPR/Cas9-based therapeutics for editing long non-coding RNAs in cancer colon cellsSemantic proximity Read

Efficient transgenesis and homology-directed gene targeting in monolayers of primary human small intestinal and colonic epithelial stem cellsSemantic proximity Read

Modeling host-microbe interactions in immunocompetent engineered human gut tissuesSemantic proximity Read

Anal skin-like epithelium mediates colonic wound healingSemantic proximity Read

Functional mRNA delivery to hematopoietic stem and progenitor cells <i>in vivo</i>Semantic proximity Read

Genetically-programmed Hypervesiculation of <i>Lactiplantibacillus plantarum</i> Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease ModelSemantic proximity Read

Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancerSemantic proximity Read

Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical TargetsSemantic proximity Read

MicroRNA-200 Loaded Lipid Nanoparticles Promote Intestinal Epithelium Regeneration in Canonical MicroRNA-Deficient MiceSemantic proximity Read