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Orthogonal validation of PD Biomarkers: Multi-platform proteomics profiling of CSF, Plasma, and Urine confirms DDC as a consistent candidate

2025-09-28

Abstract excerpt

<h4>Background</h4> High throughput proteomics has enabled hypothesis free biomarker discovery. However, differences in sample sizes, biological fluid, and quantification technologies have limited replication and validation of the results, and studies on the cross-platform variability are lacking. Here, we present the first orthogonal validation across three platforms in Parkinson’s disease (PD) to understand the...

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Literature Corpus work
19b141fa-c86b-5e9a-adbf-298a03206520
DOI
10.1101/2025.09.25.25336658
Open publication

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Orthogonal validation of PD Biomarkers: Multi-platform proteomics profiling of CSF, Plasma, and Urine confirms DDC as a consistent candidateDOI 10.1101/2025.09.25.25336658
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